The subthalamic nucleus: A possible target for stereotaxic surgery in parkinson's disease
Identifieur interne : 005D13 ( Main/Exploration ); précédent : 005D12; suivant : 005D14The subthalamic nucleus: A possible target for stereotaxic surgery in parkinson's disease
Auteurs : J. Guridi [Espagne] ; M. R. Luquin [Espagne] ; M. T. Herrero [Espagne] ; Obeso [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1993.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Animals, Basal Ganglia (anatomy & histology), Basal Ganglia (physiopathology), Basal Ganglia (surgery), Dopamine (physiology), Female, Globus Pallidus (physiopathology), Haplorhini, Human, Male, Neural Pathways, Nucleus, Parkinson Disease (physiopathology), Parkinson Disease (surgery), Parkinson disease, Parkinson's disease, Receptors, Glutamate (physiology), Stereotaxic Techniques, Stereotaxic surgery, Subthalamic, Subthalamic nucleus, Surgery, Thalamic Nuclei (physiopathology), Thalamic Nuclei (surgery), Treatment, gamma-Aminobutyric Acid (physiology), stereotaxic.
- MESH :
- chemical , physiology : Dopamine, Receptors, Glutamate, gamma-Aminobutyric Acid.
- anatomy & histology : Basal Ganglia.
- physiopathology : Basal Ganglia, Globus Pallidus, Parkinson Disease, Thalamic Nuclei.
- surgery : Basal Ganglia, Parkinson Disease, Thalamic Nuclei.
- Animals, Female, Haplorhini, Male, Neural Pathways, Stereotaxic Techniques.
Abstract
Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.
Url:
DOI: 10.1002/mds.870080402
Affiliations:
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Le document en format XML
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Herrero</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Unit and Experimental Neurology Group, Department of Neurology, Clinica Universitaria, Hospital of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Obeso" sort="Obeso" uniqKey="Obeso" last="Obeso">Obeso</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Movement Disorders Unit and Experimental Neurology Group, Department of Neurology, Clinica Universitaria, Hospital of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Guridi, J" sort="Guridi, J" uniqKey="Guridi J" first="J." last="Guridi">J. Guridi</name></noRegion><name sortKey="Herrero, M T" sort="Herrero, M T" uniqKey="Herrero M" first="M. T." last="Herrero">M. T. Herrero</name><name sortKey="Luquin, M R" sort="Luquin, M R" uniqKey="Luquin M" first="M. R." last="Luquin">M. R. Luquin</name><name sortKey="Obeso" sort="Obeso" uniqKey="Obeso" last="Obeso">Obeso</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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